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Figure 1 MiR-145 is highly conserved across vertebrates. (a,b) Homo sapiens CARMN-209 and Danio rerio BX088707.3-201 transcripts containing miR-143 (in black) and miR-145 (in gray) precursors. Exons are represented with dark blue boxes and introns with light blue lines. Scale bar represents 1kb. (c) Schematic representation of synteny analysis of miR-143/miR-145 cluster between Homo sapiens and Danio rerio. Blocks of genes in the same order are highlighted in green, while those blocks that are inverted are in yellow. Only conserved genes are shown. (d) Clustal Omega alignment of miR-145 precursor, displaying taxonomic tree on the left and aligned sequences on the right. Asterisks at the bottom represent 100% conserved bases. The mature miR-145-5p sequence is underlined on the left, with the seed sequence highlighted in gray. Some species that also possess annotated mature miR-145-3p are underlined on the right.