IMAGE

Fig. 7

ID
ZDB-IMAGE-210611-32
Source
Figures for Griffin et al., 2021
Image
Figure Caption

Fig. 7 Automated detection of behavioral seizure-like events.

a Example of low-speed movement in a WT larva (green), high-speed movement in the same WT larva (orange), and seizure-like movement in a PTZ-treated larva (red). Top traces represent the larvae track during 15 min recording in a 96-well plate. The bottom panels show speed values across time for the events highlighted. Note the short and long duration in the high-speed events in WT and PTZ-treated larvae, respectively. b Distribution of maximum speed and duration across all movements in WT (N = 109 larvae) during the 15-minute recording session. The average maximum speed was 10.5 mm/sec and the duration of the events was <1 s. c Frequency of seizure-like movements (defined as events with maximum speed >28 mm/sec and duration >1 s) in control and PTZ-treated larvae at different concentrations after 10, 30, and 60 minutes (two-way ANOVA p < 0.05). Note the increased number of events with increasing PTZ dose and the lower number when using 15 mM after 60 minutes owing to increased larvae mortality. Data displayed as mean ± SEM.

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Commun Biol