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Figure 3—figure supplement 1. Paralog substitution analysis yields similar results using the SAMap manifold constructed from one-to-one orthologs.

Comparison of substitution rates for different paralog ages (A) and cell type substitution scores (B) calculated from the original frog-zebrafish manifold versus the manifold generated using only one-to-one orthologs. (C) Histogram showing the distribution of correlation differences for paralog substitutions specific to the original (teal) and one-to-one ortholog based analyses (orange), along with those identified in both mappings (blue). Note that the majority of substitution events, especially in the large correlation difference regime, are present in both mapped manifolds.

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