ZFIN Image: van der Niet et al., 2021, FIG 5

Image

Figure Caption

FIG 5

Early cytosolic localization of M. tuberculosis in SCID mouse lungs. (A and B) Sections of SCID mouse lung tissue infected with M. tuberculosis H37Rv for 21 days were labeled for LAMP1 using immunogold labeling to indicate lysosomes. (A′ and B′) Schematic representations, with orange indicating M. tuberculosis, blue lines indicating host membranes, black dots representing gold particles indicating LAMP1-decorated lysosomes, and green indicating mitochondria. Panel A shows a cross section of M. tuberculosis surrounded by cellular membranes, which is thus phagosomal. Panel B shows M. tuberculosis present in the cytosol, without cellular membranes surrounding the bacteria. For information on the number of imaged bacteria and mice, see Table S1 in the supplemental material.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ mSphere