Figure 3.

Figure 3.

Editing in zebrafish repeats. (A) RNA editing index (defined as the editing level averaged over all edited and unedited adenosines) measured across all repeat families. The editing index varies across repeat families and is not enriched in a specific repeat family. The repeats ordered by their abundance in the genome (abundance percentage is shown within each bar). The blue line represents the maximal index of the next most frequent substitution (C-to-T mismatch in low complexity repeat family, value of 0.32%). (B) Prediction of the secondary structure of the most edited repeats. Upper structure represents the palindromic repeat, ANGEL, a member of hAT repeat family (using mfold (89)). Here, we show the most prominent single ANGEL repeat, with 62 unique editing sites (62/63 adenosines). Edited adenosines are marked in yellow; The lower structure represents a prediction of the secondary structure (using mfold (89)) of two reverse oriented HE1_DR1 repeats, members of SINE elements (tRNA-V family). (C) Global repeats editing index measured across six different brain regions.