ZFIN Image: Li et al., 2020, Fig. 4.

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Figure Caption

Fig. 4.

A cartoon illustrating pathways involved in zebrafish embryonic angiogenesis. SHH is a master regulator of angiogenesis and it regulates VEGF/VEGFR2. Neuropilin as a co-receptor is important for VEGF-VEGFR2 interaction and signaling, and regulates Semaphorin-PlexinD1 signaling. VEGFR2 signaling leads to vessel sprouting, whereas PlexinD1 signaling restricts angiogenesis and regulates vessel patterning. VEGFR2 induces regulates Dll4/Notch signaling, which in turn determines vessel specification (EphB4 on vein and EphrinB2 on artery) and vessel stability through Nrarp.

Acknowledgments

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