ZFIN Image: Wang et al., 2021, FIGURE 3

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Figure Caption

FIGURE 3

Vascular lumens were collapsed after ibrutinib treatment. (A) Confocal images of the dorsal aorta (DA) and posterior cardinal vein (PCV) in the trunk of ibrutinib-treated Tg (kdrl:EGFP) embryos at 72 h post-fertilization (hpf). Scale bar: 50 μm. (B) H&E staining of cross-sections containing the DA and PCV of treated embryos at 72 hpf. Scale bar: 20 μm. (C) Immunofluorescence staining of cross-sections containing the DA and PCV of treated embryos at 72 hpf. Scale bar: 10 μm. (D) Diameters of the DA and PCV in treated embryos at 72 hpf; n = 10 for each group. Asterisks indicate significant differences (DMSO vs. ibrutinib), ***p < 0.001.

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