ZFIN Image: Gerrard et al., 2020, Fig. 7

Image

Figure Caption

Fig. 7 Neurodevelopmental de novo mutation within brain-specific histone modification correlated to surrounding gene expression.

An intergenic G-to-T de novo mutation (DNM; hg38, chr16:72427838) is shown for a patient with a neurodevelopmental phenotype. Tracks are shown demonstrating additional human embryonic non-coding transcription (enriched in human embryonic brain), the three epigenomic marks, ENCODE data²⁶ and conservation amongst vertebrates. The DNM overlaps a brain-specific (dark blue) H3K27ac and small H3K4me3 mark. The highest correlations are shown, notably to the promotors of ZNF821 (r = 0.92) (dark blue) with anticorrelation (r = −0.65, red) to the adjacent gene, ATXN1L.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.