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Fig. s4 Dynamics of otx2b, otx1, and gbx1 response to hs:wnt8a. In situ hybridization of otx2b (A,B), gbx1 (C,D), and otx1 (E,F). 12 hpf embryos, lateral view, anterior left, dorsal up. (A,B) otx2b is not repressed by Wnt activation 4 hours post heat shock. (C,D) gbx1 expansion into anterior neural plate is observed 6 hours after induction of hs:wnt8a. This phenotype correlates with the absence of both otx1 expression (E,F) and otx2b (see Fig. 5D).
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Reprinted from Developmental Biology, 462(2), Green, D.G., Whitener, A.E., Mohanty, S., Mistretta, B., Gunaratne, P., Yeh, A.T., Lekven, A.C., Wnt signaling regulates neural plate patterning in distinct temporal phases with dynamic transcriptional outputs, 152-164, Copyright (2020) with permission from Elsevier. Full text @ Dev. Biol.