IMAGE

Figure 4

ID
ZDB-IMAGE-200423-71
Source
Figures for Cozzolino et al., 2020
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Figure Caption

Figure 4

Localization of the sources of the LFP transients. (A) Maps obtained by computing the cross-correlation of the Ca2+ fluctuations of each pixel with the logarithm of the RMS (Root Mean Sqaure) power in the band 30–95 Hz in the three experimental models. (B) Example of recordings from a PTZ-treated larva where the correlation between the largest electrophysiological events (labelled by an asterisk) and Ca2+ activity measured in the OT (green trace) is apparent, and in the MOb (pink trace). (C) Ca2+ fluctuations measured in the Cb (orange trace, represented as an area to better appreciate details) correlate with both the large RMS events and the smaller interictal-like transients. (D) ΔF/F0 of the frames corresponding to baseline electrophysiological activity (labelled 1 in the above panels), to a small interictal event (2), in which Ca2+ activity is sparse and mostly localized in the Cb, and to a large electrophysiological event (3) associated to generalized Ca2+ activation. The overlay shows ΔF/F0 fluctuations larger than 10% over-imposed on the mean projection of the image stack.

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