FIG 6

FIG 6

Model: PecA processes PE-PGRS proteins and is important for virulence. (A) PecA removes the PE domain of PE-PGRS proteins, including LipY_tub and itself, at the surface of Mycobacterium marinum. The processed PE_PGRS proteins might be of importance during infection, although their exact role, as well as the fate of the PE domains, remains unknown. (B) Proteolytic activity of PecA is suggested to play a role in virulence of M. marinum, as was observed during infection in zebrafish larvae.