ZFIN Image: Ayala-Nunez et al., 2019, Fig. 1

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Figure Caption

Fig. 1

Monocyte-derived cells are infected by ZIKV in a human fetus with microcephaly. a–e Immunohistochemical staining was performed on human fetal brain tissues from a PCR-confirmed case of congenital ZIKV (gestational age 22 weeks). All slides were counterstained in Mayer’s Hematoxylin and blued in Lithium carbonate. The tissue slices were stained for ZIKV–NS1 in combination with a CD45 (left panel: 63×, right panel: 40×), b CD14 (20×), c CD68 (upper panel: 63×, lower left panel: 100×, and lower right panel: 40×), or d CD163 (upper panel: 40×, lower left panel: 100×, and lower right panel: 63×). e The endothelial cells of slices from the same tissue appear morphologically intact and were never found positive for ZIKV–NS1 staining. The black arrowheads indicate ZIKV-infected cells. BV blood vessel

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