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Figure 1

AGPCRs are gigantic molecules that share characteristic features as a GPCR autoproteolysis inducing (GAIN) domain which harbors the GPCR proteolytic site (GPS), at which the receptor is cleaved into an N-terminal (NTF) and a C-terminal fragment (CTF). A tethered peptide agonist called the Stachel sequence (red) or derived peptides activate the receptor.

Acknowledgments

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