ZFIN Image: Toms et al., 2019, Fig. 1

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Figure Caption

Fig. 1

Retinal structure and function in obe^td15 zebrafish. (a) Wholemount morphology of adult wild-type (WT) and obe^td15zebrafish. (b) Retinal histology of obe^td15 zebrafish at 3, 6 and 12 months post fertilization (mpf). (c) Expression of kcnj13mRNA (green) in the WT adult zebrafish retina detected using an RNAscope assay. Sections are counterstained with DAPI nucleic acid stain (blue). (d) Visual acuity (cycles per degree) of obe^td15 zebrafish at 3, 6 and 12 mpf, measured using optokinetic response assay (minimum n = 4, mean ± SEM). (e) Retinal thickness (µm) of obe^td15 zebrafish at 3, 6 and 12 mpf, measured using OCT (n = 5 for each age, mean ± SEM). GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer; IS/OS, outer and inner segments; RPE, retinal pigment epithelium. *p < 0.05, **p < 0.01. Scale bars = 50 μm (b) and 25 μm (c).

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Acknowledgments

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