Gene

kcnj13

ID

ZDB-GENE-070129-1

Name

potassium inwardly rectifying channel subfamily J member 13

Symbol

kcnj13 Nomenclature History

Previous Names

kir7.1 (1)
jag
jaguar
obe
obelix

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Is predicted to enable inward rectifier potassium channel activity. Involved in potassium ion import across plasma membrane and regulation of ion transmembrane transport. Acts upstream of or within establishment of pigment granule localization; melanocyte differentiation; and melanocyte migration. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in brain; caudal fin; eye; gonad; and integument. Used to study Leber congenital amaurosis. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 16 and snowflake vitreoretinal degeneration. Orthologous to human KCNJ13 (potassium inwardly rectifying channel subfamily J member 13).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 24 figures from 10 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kcnj13 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Leber congenital amaurosis 16	Alliance	Leber congenital amaurosis 16	614186
snowflake vitreoretinal degeneration	Alliance	Snowflake vitreoretinal degeneration	193230

Associated With kcnj13 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Leber congenital amaurosis	kcnj13^td15/td15	standard conditions	Toms et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR040445	Potassium channel, inwardly rectifying, transmembrane domain
Domain	IPR041647	Inward rectifier potassium channel, C-terminal
Family	IPR008062	Inward rectifier potassium channel 13
Family	IPR016449	Potassium channel, inwardly rectifying, Kir
Homologous_superfamily	IPR013518	Potassium channel, inwardly rectifying, Kir, cytoplasmic
Homologous_superfamily	IPR014756	Immunoglobulin E-set

Domain Details Per Protein

Protein	Length	Immunoglobulin E-set	Inward rectifier potassium channel 13	Inward rectifier potassium channel, C-terminal	Potassium channel, inwardly rectifying, Kir	Potassium channel, inwardly rectifying, Kir, cytoplasmic	Potassium channel, inwardly rectifying, transmembrane domain
UniProtKB:Q0KIZ7 InterPro	362

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
antisense	ottdart00000060027 (1) Ensembl	1536 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	kcnj13-202 (1) Ensembl	6855 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations