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Yang et al., 2018 - Interaction of hepatic stellate cells with neutrophils and macrophages in the liver following oncogenic kras activation in transgenic zebrafish

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Fig. 6

Effect of inhibition of Tgfb signaling on liver tumorigenesis and pro-tumor gene expression in hepatocytes, neutrophils and macrophages. 3-dpf wildtype or kras+ larvae were treated with dox and SB431542 for 4 days. (A,B) Gross morphology of larvae after 4 days treatments (A) and quantification of liver size (B). (C–E) Expression of selected genes for pro-fibrosis, EMT and anti-tumor in hepatocytes (C), neutrophils (D) and macrophages (E). Fold changes refer the expression levels in kras+ larvae versus wildtype larvae. In all experiments, n = 20 for each group. *P < 0.05. Error bars represent biological replicates in (B) and technical replicates in (C), (D) and (E). Scale bars: 20 μm.

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