ZFIN Image: Yang et al., 2018, Fig. 6

Image

Figure Caption

Fig. 6

Effect of inhibition of Tgfb signaling on liver tumorigenesis and pro-tumor gene expression in hepatocytes, neutrophils and macrophages. 3-dpf wildtype or kras+ larvae were treated with dox and SB431542 for 4 days. (A,B) Gross morphology of larvae after 4 days treatments (A) and quantification of liver size (B). (C–E) Expression of selected genes for pro-fibrosis, EMT and anti-tumor in hepatocytes (C), neutrophils (D) and macrophages (E). Fold changes refer the expression levels in kras+ larvae versus wildtype larvae. In all experiments, n = 20 for each group. *P < 0.05. Error bars represent biological replicates in (B) and technical replicates in (C), (D) and (E). Scale bars: 20 μm.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Sci. Rep.