ZFIN Image: Gou et al., 2018, Fig. 3

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Fig. 3

Effects of high-level misexpression ofsox2orsox3during early placode development. (A–H) Dorsolateral views (anterior to the left) of expression of atoh1a (A–D) and neurog1 (E–H) at 24 hpf in control (A, E), hs:sox2/hs:sox2 (B, F) and hs:sox3/hs:sox3 (C–H) embryos. (I–N) Expression of atoh1a (I–K) and neurog1 (L–N) at 24 hpf in cross sections (lateral to the left) through the middle of the otic vesicle in hs:sox2/hs:sox2 homozygotes (I, L) and hs:sox3/hs:sox3 homozygotes (J, K, M, N). hs:sox2/hs:sox2 homozygotes were heat shocked at 12.5 hpf, 39 °C for 60 min, whereas hs:sox3/hs:sox3 homozygotes were heat shocked at 12.5 hpf, 38 °C for 30 min. Otic vesicle borders are outlined.

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Acknowledgments

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Reprinted from Developmental Biology, 435(1), Gou, Y., Vemaraju, S., Sweet, E.M., Kwon, H.J., Riley, B.B., sox2 and sox3 play unique roles in development of hair cells and neurons in the zebrafish inner ear, 73-83, Copyright (2018) with permission from Elsevier. Full text @ Dev. Biol.