|ZFIN ID: ZDB-IMAGE-170502-4|
Overexpression of Ptpn11mut Inhibits the Developmentally Timed Apoptotic Response Triggered by MYCN Overexpression in the IRG
(A) Sagittal sections through the IRG of MYCN (top) and MYCN;ptpn11mut (bottom) transgenic fish at 5.5 wpf (dorsal up, anterior left). GFP, green; activated caspase-3, red; DAPI, blue. Arrowheads point to the activated caspase-3+ apoptotic cells. Dotted lines indicate the head kidney (HK) boundary. Scale bars, 10 μm.
(B) Percentage of activated caspase-3+ apoptotic cells to the total number of GFP+ sympathetic neuroblasts in the IRG of MYCN and MYCN;ptpn11mut fish at 5.5 wpf. Mean values (horizontal bars) were compared by the Welch t test (two-tailed).
|Acknowledgments:||This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.|