ZFIN Image: Bielczyk-Maczyńska et al., 2015, Fig. 8

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Figure Caption

Fig. 8

nol9^{sa1022/sa1022} embryos display tissue-specific upregulation of tp53.

Representative images of embryos stained by whole-mount in situ hybridization against tp53. (A) At 48 hpf, similar levels of tp53 signal (arrow) was detected in the CHT of nol9^{sa1022/sa1022} embryos and their wild-type siblings. (B) At 72 hpf, nol9^{sa1022/sa1022} mutant embryos were characterized by more tp53 signal in the CHT than their wt siblings. Mann-Whitney U test, p<0.05. (A-B) All embryos are oriented with anterior to the left and dorsal to the top. (C) Schematic representation of digestive organs in a wild-type 72 hpf zebrafish larva. I–intestine, L- liver, P- pancreas. (D) At 72 hpf, nol9^{sa1022/sa1022} mutant embryos display strong tp53 signal in the liver (arrowhead) and intestine (arrow), compared to weak signal in the intestine of wild-type siblings. (C-D) Dorsal view anterior up.

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Acknowledgments

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