ZFIN Image: Takacs et al., 2016, Fig. 2

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Figure Caption

Fig. 2

MZdicer neural progenitors in dorsal regions fail to cross midline. (A) Lineage tracing after unilateral Kaede photoconversion at 11 hpf. (B–E) Kaede lineage tracing after photoconversion (3-5 somites; B and D) and ~8 h later (20 somites; C and E). (B–C) Wildtype neural progenitors undergo bilateral distribution. (D–E) In contrast, MZdicer neural progenitors retain unilateral distribution in dorsal regions of the neural anlage. Arrowhead demarcates the presumptive neural midline. (F–H) Cell cycle inhibition reduces MZdicer ectopic neural cell accumulation. Asterisk indicates presence of ectopic cell aggregate. Arrowheads indicate apical membrane. OV, otic vesicle.

Acknowledgments

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Reprinted from Developmental Biology, 409(2), Takacs, C.M., Giraldez, A.J., miR-430 regulates oriented cell division during neural tube development in zebrafish, 442-50, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.