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Fig. S6
Co-injection of insa mRNA rescues the expansion of β cells in insaMO-injected islets. (A-C′) Merged and single channel confocal projection of 24 hpf Tg(ins:CFP-NTR) control (A,A′), insaMO-injected (B,B′), and insaMO + insa mRNA-injected (C,C′) islets immunostained for CFP (β cells, green), Pdx1 (red), and DNA (blue). (D) Quantification of β cells in control, insaMO-injected, and insaMO + insa mRNA-injected islets. The expansion of β cell mass observed in insaMO-injected islets is rescued when insa mRNA is co-injected.
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Reprinted from Developmental Biology, 409(2), Ye, L., Robertson, M.A., Mastracci, T.L., Anderson, R.M., An insulin signaling feedback loop regulates pancreas progenitor cell differentiation during islet development and regeneration, 354-69, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.