ZFIN Image: Xu et al., 2015, Fig. 4

Image

Figure Caption

Fig. 4

The Microglia in the Eye Exhibit Distinct Colonization and Composition Profile to the Microglia in the CNS

(A) The RBI- but not VDA- and PBI-region-derived cells (coro1a-GFP⁺ cells) constitute the major population of microglia (Lcp1⁺ cells) in the eyes (indicated by dashed lines) of 4-dpf zebrafish. White arrows indicate coro1a-GFP⁺ microglia in the eyes.

(B) The RBI- and VDA- but not PBI-region-derived cells (coro1a-GFP⁺ cells) constitute the major population of microglia (Lcp1⁺ cells) in the 3-month adult zebrafish eye. White arrows indicate the coro1a-GFP⁺ microglia in the eyes.

(C) Quantification of the contribution of the RBI-, VDA-, and PBI-region-derived microglia in the developing and adult zebrafish eyes. For the RBI-labeled 4-dpf, 15-dpf, 1.5-month, 3-month, and 1-year adult fish, n = 8, 8, 5, 8, and 10, respectively; for the VDA-region-labeled 4-dpf, 15-dpf, 1.5-month, 3-month, and 1-year adult fish, n = 5, 6, 5, 8, and 9, respectively; for the PBI-labeled 4-dpf, 15-dpf, 1.5-month, and 3-month adult fish, n = 7, 6, 7, and 8, respectively. Error bars represent mean ± SEM. p < 0.05; p < 0.01; p < 0.001.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Cell, 34, Xu, J., Zhu, L., He, S., Wu, Y., Jin, W., Yu, T., Qu, J.Y., Wen, Z., Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish, 632-641, Copyright (2015) with permission from Elsevier. Full text @ Dev. Cell