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Fig. S2
Induction of VP-RAR expression using the Tg(hsp70l:EGFP-VP-RAR) line promotes cyp26a1 expression at later stages. (A,B) Wholemount ISH shows cyp26a1 expression is increased after heat-shock at 26 hpf. (C–F) cyp26b1 is modestly increased after heat-shock at 26 hpf in the head, while cyp26c1 is unchanged. (G–J) Rdh10a expression was decreased after heat-shock at 26 hpf, but aldh1a2 expression was overtly unchanged. GFP- denotes non-transgenic siblings, GFP+ denotes embryos with the hsp70l:EGFP-VP-RAR transgene.
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Reprinted from Developmental Biology, 405(1), Rydeen, A., Voisin, N., D'Aniello, E., Ravisankar, P., Devignes, C.S., Waxman, J.S., Excessive feedback of Cyp26a1 promotes cell non-autonomous loss of retinoic acid signaling, 47-55, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.