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Fig. 4
Cyp26a1 is required for induction of RA loss of function. (A,C) Gir-/- embryos have expanded hoxb5b expression relative to their siblings. (B,D) Gir-/- embryos injected with vp-rar mRNA have expanded hoxb5b expression, while the remaining gir+/? Embryos lose hoxb5b expression. (E–H) ISH for the sekm cktl and rdh10a in embryos from a gir+/- adult cross show that vp-rar mRNA injected embryos still showed brain defects and rdh10a expression was unchanged.
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Reprinted from Developmental Biology, 405(1), Rydeen, A., Voisin, N., D'Aniello, E., Ravisankar, P., Devignes, C.S., Waxman, J.S., Excessive feedback of Cyp26a1 promotes cell non-autonomous loss of retinoic acid signaling, 47-55, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.