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Fig. 6
Label retaining support cells are localized to the anterior region of caudal fin neuromasts. (A) Schematic illustrating the orientation of neuromasts in the caudal fin that were analyzed; applies to panels B and C (B) representative z-stack confocal maximum projection image of an adult Tg(actb2:NLS-Eos) neuromast following entire neuromast Eos photoactivation (PA) and 6 sequential hair cell regeneration cycles. Scale bar, 10 µM. (C) Diagram illustrating the distribution of label retaining cells using the red fluorescence intensity smooth median regression of 23 overlaid neuromasts. N=4 adult zebrafish.
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Reprinted from Developmental Biology, 402(2), Cruz, I.A., Kappedal, R., Mackenzie, S.M., Hailey, D.W., Hoffman, T.L., Schilling, T.F., Raible, D.W., Robust regeneration of adult zebrafish lateral line hair cells reflects continued precursor pool maintenance, 229-38, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.