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Fig. 1

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ZDB-IMAGE-140313-28
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Source
Figures for Fekany et al., 1999
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Figure Caption

Fig. 1 bozm168 causes deficiencies in dorsal and anterior embryonic structures with variable penetrance and expressivity. (A) boz mutant classes. From right to left, lateral views of wild-type, class V, class IV, class III and two class II boz larvae (3 dpf). There is a break in the notochord of class V boz larva, while the class IV mutant has a gap in notochord, spanning many somites. The class III mutant exhibits a gap in notochord and partially fused eyes, while class II mutants lack notochord completely and display cyclopia. (B,C) The neural keel in class II boz mutant embryos is highly abnormal, and the most anterior structures are missing (C), compared to wild type (B) (10-somite stage). (D,E) In wild-type embryos, emx1 (blue) is expressed in the forebrain (fb) and krox20 (red) in hindbrain rhombomeres R3 and R5 (D). In bozm168 class I embryos, emx1 expression is absent, while the krox20 expression domains appear enlarged (E) (17 hpf, lateral views). Scale bar, 200 μm.

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