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Fig. 1

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ZDB-IMAGE-130510-1
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Figures for Münch et al., 2013
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Fig. 1

Notch signalling is activated during fin regeneration. (A) qPCR analysis of notch1b, lfng, her6 and her15 mRNA in regenerating fins at 3 dpa relative to expression in non-amputated fins (0 dpa). *P<0.05, **P<0.01. (B-F) Whole-mount in situ hybridization in 2 dpa fins for jag1b (B), notch1b (C), lfng (D), her6 (E) and her15 (F), showing Notch pathway activation within the blastema (arrowheads). (G) Scheme of a 3 dpa fin section, indicating the two regions within the regenerate: the blastema (b) and the differentiation zone (dz). Green indicates regenerating fin rays. (H-J) In situ hybridization on 3 dpa fin sections for jag1b (H), lfng (I) and her6 (J) reveals Notch pathway activation in the blastema (b, arrowhead), but weak or no gene expression within the dz (arrow). Scale bars: 100 μm in C,F; 10 μm in J. Broken lines mark amputation plane.

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