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Fig. 6 Impaired melanosome transport in Inpp5e morphants. (A) Inpp5e morphants showed slowed retrograde melanosome transport. Five day-old larvas injected with morpholinos were treated with epinephrine, and the time required for all melanosomes in the head and trunk to retract was determined. Representative photos are shown. (B) Quantification of the response time for epinephrine treatments in the control MO (2 ng), Inpp5e MO (2 ng), and Inpp5e MO (2 ng) and hINPP5E mRNA (400 pg) embryos (N = 20 embryos, three independent experiments, unpaired t-test, * p = 1.17E18, ** p = 1.5E12).
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Reprinted from Vision Research, 75, Luo, N., Lu, J., and Sun, Y., Evidence of a role of inositol polyphosphate 5-phosphatase INPP5E in cilia formation in zebrafish, 98-107, Copyright (2012) with permission from Elsevier. Full text @ Vision Res.