ZFIN Image: Ferri-Lagneau et al., 2012, Fig. S5

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Figure Caption

Fig. S5 Bmp antagonists, that inhibit the canonical BMP-Smad signaling pathway, suppress the ginger-induced bmp2b expression in the region of the developing CHT. Whole mount in situ hybridization of bmp2b expression in zebrafish embryos after treatment with Bmp inhibitors and/or ginger/10-G from 10 to 48 hpf. (A) A control embryo. (B) Zebrafish embryos treated with ginger (5 µg/ml). (C–D) Ginger (5 μg/ml) and Dorsomorphin/DMP, 0.1 and 2 μM. (E–G) Ginger (5 μg/ml) and LDN193189, 0.1, 0.5 and 1 μM. (H) Ginger (5 μg/ml) and DMH1, 0.1 μM. (I) Analyses of bmp2b expression localized in the CHT area (table). Scale bars = 300 μm.

Acknowledgments

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