ZFIN Image: Nachtrab et al., 2011, Fig. 4

Image

Figure Caption

Fig. 4 GSK3 Inhibition Rescues Fin Regeneration

(A) Blastemal proliferation in anterior portions of 4 dpa pectoral fin regenerates from vehicle- and BIO-treated males, assessed by H3P staining. Arrowheads indicate amputation plane.

(B) Treatment with 100 nM BIO for 4 days after amputation increased male anterior blastemal proliferation by 56%. Female blastemal proliferation was not affected by BIO (n = 26–30 males, n = 12 females). ^*p < 0.001 by Student′s t test.

(C and D) Four days of BIO or FEN treatment after amputation, followed by 3 days without treatment, increased male anterior regenerate lengths by 47% and 48%, respectively, over vehicle alone (n = 22–24 BIO, n = 8 FEN). ^*p < 0.001 by Student′s t test.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Curr. Biol.