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Fig. 3 Heritable T-cell malignancies are transplantable and can be easily visualized by fluorescent protein expression in leukemic cells (modified from Frazer et al.41). Green fluorescent protein (GFP+) leukemias from shrek (srk; A–C), hulk (hlk; D–F), and oscar the grouch (otg; G–I) mutants were transplanted into irradiated wild-type hosts. At 1 week, GFP+ cells were seen at the site of transplantation (A, D, G). Subsequently, tumors spread locally (B, E, H) and then disseminated widely (C, F, I).
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