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Fig. 6

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ZDB-IMAGE-080401-40
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Figures for Ignatius et al., 2008
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Fig. 6 Repression of Foxd3 rescues melanogenesis in hdac1col mutants. Images of live embryos at 3 dpf, (A–D) lateral views, (E–H) dorsal views. (A, B) There are fewer melanophores present in hdac1col mutants at 3 dpf compared to wild-type embryos. Melanophores present in hdac1col mutants fail to migrate and are present at the site of origin in the post otic region, in the dorsal (d) stripe and in the anterior ventral stripe. In wild-type embryos, melanophores migrate to form four stripes; dorsal (d), lateral (l), ventral (v) and yolk (y). (C, D) Partial knockdown of Foxd3 in hdac1col mutants increases melanophore numbers and the melanophores migrate over the head (arrowhead), into the ventral stripe and over the yolk. (E, F) In control uninjected hdac1col mutants the dorsal stripe (d) is usually 3–5 melanophores wide (arrowhead), in comparison the wild-type dorsal stripe is 2ipe and over the yolk. (E, F) In control uninjected hdac1col mutants the dorsal stripe %–3 melanophores wide (arrowhead). (G, H) Partially reducing Foxd3 with a translation blocking morpholino (mo) in hdac1col mutants increases the migration of melanophores into the ventral stripe and over the yolk, the resulting dorsal stripe in hdac1col/foxd3 mo mutant/morphants is only 2–3 melanophores wide (arrowhead).

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Reprinted from Developmental Biology, 313(2), Ignatius, M.S., Moose, H.E., El-Hodiri, H.M., and Henion, P.D., colgate/hdac1 repression of foxd3 expression is required to permit mitfa-dependent melanogenesis, 568-583, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.