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Fig. S1 Cell cycle analysis of int6 morphants. Whole-mount immunohistochemistry with the late G2/M phase marker, phospho-histone H3 shows only slightly reduced numbers of cells in late G2/M phase in the int6 morphant compared to the control. Similarly, DNA content as measured by flow cytometry reveals only a slight reduction of cells in G2/M phase in the int6 morphant. Thus, we find that loss of Int6 in normal vertebrate cells (as well as in additional human cancer cell lines, M.G. & C.J.N. unpublished data) does not appear result in an accumulation of cells in G2/M progression.
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