ZFIN Image: Xiong et al., 2006, Fig. S11

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Figure Caption

Fig. S11 Effects of tob1a in MZoep Mutants and on Mesodermal and Endodermal Markers (A) Effects of tob1a overexpression in MZoep mutants. Injection with tob1a mRNA caused loss of a head (indicated by arrowheads) and expansion of caudal ventral region (indicated by arrows) at 24 hpf (top panel). Orientations of embryos for expression of marker genes (in blue letters): animal-pole views with the dorsal to right) for chordin (chd) and gata2 at the shield stage; dorsoanterior views for otx2 at the bud stage; and lateral views with the dorsal to right for bmp2b at the shield stage. (B) Embryos were injected with 20 ng of tob1a-MO or 400 pg of tob1a mRNA and examined for expression of the mesodermal marker ntl at the shield stage and the endodermal marker sox32 at the shield stage and sox17 at the 75% epiboly stage. The first and the third panels, lateral views with the dorsal to right; the second panel, animal-pole views with the dorsal to right; the fourth panel, dorsal views with the animal-pole to top.

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Acknowledgments

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Reprinted from Developmental Cell, 11(2), Xiong, B., Rui, Y., Zhang, M., Shi, K., Jia, S., Tian, T., Yin, K., Huang, H., Lin, S., Zhao, X., Chen, Y., Chen, Y.G., Lin, S.C., and Meng, A., Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity, 225-238, Copyright (2006) with permission from Elsevier. Full text @ Dev. Cell