ZFIN Image: Albertson et al., 2005, Fig. 4

Image

Figure Caption

Fig. 4 ace/fgf8 mutants exhibit asymmetric pharyngeal arch development. (A–C) Cranial neural crest (CNC) segments at 36 hpf in wt and mutant larvae (black arrows). (A) Wt dlx2 expression in 7 bilateral CNC segments. (B, C) Age-matched ace/fgf8 mutants exhibit fewer and often asymmetrical numbers of CNC segments. (D–F) Pharyngeal endoderm pouches in wt and mutant larvae (black arrows). (D) At 32 hpf, wt larvae possess a bilateral series of pharyngeal endodermal pouches, revealed via nkx2.3 expression. (E, F) In some ace/fgf8 mutants, the pharyngeal endoderm develops asymmetrically, with fewer endodermal pouches apparent on the right side of the pharynx.

Acknowledgments

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Reprinted from Developmental Biology, 283(2), Albertson, R.C., and Yelick, P.C., Roles for fgf8 signaling in left-right patterning of the visceral organs and craniofacial skeleton, 310-321, Copyright (2005) with permission from Elsevier. Full text @ Dev. Biol.