ZFIN Image: Albertson et al., 2005, Fig. 1

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Figure Caption

Fig. 1 fgf8 is required for LR asymmetric development of the viscera and morphogenesis of Kupffer′s vesicle (KV). (A–B) By 7 dpf the gall bladder (gb) and pancreas (p) autofluorescence under UV illumination, providing a simple screen for LR situs defects. (A) Wt larvae typically exhibit normal LR situs positioning (situs solus), with the gall bladder to the right of the midline and the pancreas to the left. (B) Approximately 30% of ace/fgf8 mutants exhibit randomized LR situs positioning, including situs inversus. (C) KV is apparent in wt embryos by the five somate stage (black arrow). (D) KV does not develop in approximately 30% of ace/fgf8 mutants (white arrow where KV should be).

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Acknowledgments

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Reprinted from Developmental Biology, 283(2), Albertson, R.C., and Yelick, P.C., Roles for fgf8 signaling in left-right patterning of the visceral organs and craniofacial skeleton, 310-321, Copyright (2005) with permission from Elsevier. Full text @ Dev. Biol.