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Fig. 7 Alk4 S275M rescues left–right patterning in SB-431542-treated Xenopus embryos. Embryos were injected on the left side only with 150 pg xAlk4-GR S275M (A, B) or xAlk4-GR WT (C, D) mRNA and treated with 10 μM Dexamethasone at stage 13.5 followed by 100 μM SB-431542 (A, C) or DMSO (B, D) at stage 14. Embryos were processed for in situ hybridization with an xAntivin antisense probe at stage 22. Embryos were photographed with the anterior to the left and the left side showing. Note specific recovery of antivin expression (red arrow) in the left flank in panel A.
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Reprinted from Developmental Biology, 295(2), Ho, D.M., Chan, J., Bayliss, P., and Whitman, M., Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo, 730-742, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.