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Figure Caption
Fig. 5 Alk4 S275M rescues the SB-431542-induced phenotype in zebrafish embryos. Zebrafish embryos were injected with (A, B) 100 pg Alk4 S275M or (C, D) 100 pg Alk4 WT, treated with 100 μM SB-431542 or DMSO at 16-cell stage, and photographed at 24 hpf. Alk4 WT embryos display severe anterior defects (C) when treated with SB-431542, but Alk4 S275M embryos appear wild-type (A). DMSO-treated controls (B, C) appear normal, indicating that injection of the receptors alone does not affect morphology.
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Reprinted from Developmental Biology, 295(2), Ho, D.M., Chan, J., Bayliss, P., and Whitman, M., Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo, 730-742, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.