Gene
mdka
- ID
- ZDB-GENE-990621-1
- Name
- midkine a
- Symbol
- mdka Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable growth factor activity. Acts upstream of with a positive effect on positive regulation of mitotic cell cycle. Acts upstream of or within several processes, including cardiac muscle tissue regeneration; neural tube formation; and sensory epithelium regeneration. Located in Golgi apparatus. Is expressed in several structures, including heart; nervous system; neural tube; neuroectoderm; and paraxial mesoderm. Human ortholog(s) of this gene implicated in brain ischemia. Orthologous to human MDK (midkine).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 34 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| a299 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| cn105 | Allele with one delins | Exon 3 | Premature Stop | CRISPR | |
| mi5001 | Allele with one deletion | Exon 3 | Premature Stop | CRISPR | |
| pd324 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa34130 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR020089 | Pleiotrophin/Midkine, N-terminal domain |
| Domain | IPR020090 | Pleiotrophin/Midkine, C-terminal domain |
| Family | IPR000762 | Midkine heparin-binding growth factor |
| Homologous_superfamily | IPR020091 | Pleiotrophin/Midkine disulphide-rich domain superfamily |
| Homologous_superfamily | IPR037122 | Pleiotrophin/Midkine, N-terminal domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Midkine heparin-binding growth factor | Pleiotrophin/Midkine, C-terminal domain | Pleiotrophin/Midkine, C-terminal domain superfamily | Pleiotrophin/Midkine disulphide-rich domain superfamily | Pleiotrophin/Midkine, N-terminal domain | Pleiotrophin/Midkine, N-terminal domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9W767 | InterPro PDB | 146 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-210E9 | ZFIN Curated Data | |
| Encodes | EST | fb05b02 | ZFIN Curated Data | |
| Encodes | EST | fc32h11 | ||
| Encodes | cDNA | MGC:86655 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131070 (1) | 1975 nt | ||
| Genomic | GenBank:CR356225 (2) | 201825 nt | ||
| Polypeptide | UniProtKB:Q9W767 (1) | 146 aa |
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Kapuria, S., Bai, H., Fierros, J., Huang, Y., Ma, F., Yoshida, T., Aguayo, A., Kok, F., Wiens, K.M., Yip, J.K., McCain, M.L., Pellegrini, M., Nagashima, M., Hitchcock, P.F., Mochizuki, N., Lawson, N.D., Harrison, M.M.R., Lien, C.L. (2022) Heterogeneous pdgfrβ+ cells regulate coronary vessel development and revascularization during heart regeneration. Development (Cambridge, England). 149(4):
- Lübke, L., Zhang, G., Strähle, U., Rastegar, S. (2022) mdka Expression Is Associated with Quiescent Neural Stem Cells during Constitutive and Reactive Neurogenesis in the Adult Zebrafish Telencephalon. Brain sciences. 12(2):
- Lukowicz-Bedford, R.M., Farnsworth, D.R., Miller, A.C. (2022) Connexinplexity: The spatial and temporal expression of connexin genes during vertebrate organogenesis. G3 (Bethesda). 12(5):
- Grivas, D., González-Rajal, Á., de la Pompa, J.L. (2021) Midkine-a Regulates the Formation of a Fibrotic Scar During Zebrafish Heart Regeneration. Frontiers in cell and developmental biology. 9:669439
- Miklas, J.W., Levy, S., Hofsteen, P., Mex, D.I., Clark, E., Muster, J., Robitaille, A.M., Sivaram, G., Abell, L., Goodson, J.M., Pranoto, I., Madan, A., Chin, M.T., Tian, R., Murry, C.E., Moon, R.T., Wang, Y., Ruohola-Baker, H. (2021) Amino acid primed mTOR activity is essential for heart regeneration. iScience. 25:103574
- Ang, N.B., Saera-Vila, A., Walsh, C., Hitchcock, P.F., Kahana, A., Thummel, R., Nagashima, M. (2020) Midkine-a functions as a universal regulator of proliferation during epimorphic regeneration in adult zebrafish. PLoS One. 15:e0232308
- Lange, C., Rost, F., Machate, A., Reinhardt, S., Lesche, M., Weber, A., Kuscha, V., Dahl, A., Rulands, S., Brand, M. (2020) Single cell sequencing of radial glia progeny reveals diversity of newborn neurons in the adult zebrafish brain. Development (Cambridge, England). 147(1):
- Thompson, J.D., Ou, J., Lee, N., Shin, K., Cigliola, V., Song, L., Crawford, G.E., Kang, J., Poss, K.D. (2020) Identification and requirements of enhancers that direct gene expression during zebrafish fin regeneration. Development (Cambridge, England). 147(14):
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