ZFIN is now using GRCz12tu for Genomic Data
Gene
gap43
- ID
- ZDB-GENE-990415-87
- Name
- growth associated protein 43
- Symbol
- gap43 Nomenclature History
- Previous Names
-
- cb310 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable calmodulin binding activity and phospholipid binding activity. Acts upstream of or within axon regeneration and tissue regeneration. Predicted to be located in filopodium membrane; growth cone membrane; and synapse. Predicted to be active in cytoplasm; plasma membrane; and postsynaptic density. Is expressed in nervous system; neural tube; and trigeminal placode. Orthologous to human GAP43 (growth associated protein 43).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 32 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb310 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | IQ motif, EF-hand binding site | Neuromodulin (GAP-43) | Neuromodulin gap junction N-terminal | Neuromodulin, palmitoylation site | Neuromodulin, phosphorylation site |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q90462 | InterPro | 194 | |||||
| UniProtKB:A0A8M1P7P8 | InterPro | 194 |
1 - 2 of 2
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-gap43 | monoclonal | IgG2a | Mouse |
|
Sigma-Aldrich
Santa Cruz Biotechnology, Inc. |
5 |
1 - 1 of 1
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(4xen.cpce-E1B:gap43-mScarlet) |
|
| 1 | (2) | |
| Tg(5xUAS:gap43-GFP) |
|
| 1 | (19) | |
| Tg(-7.2sox10:gap43-Eos) |
|
| 1 | Takamiya et al., 2020 | |
| Tg(hsp70l:gap43-MA-ECFP) |
| 1 | Farrar et al., 2018 | ||
| Tg(UAS:gap43-EGFP-2A-Hsa.TP53_R175H) |
| 1 | Haraoka et al., 2022 | ||
| Tg(UAS:gap43-mKOFP2-2A-Hsa.HRAS_G12V) |
| 1 | Haraoka et al., 2022 |
1 - 6 of 6
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | EST | cb310 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:91783 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192992 | ZFIN Curated Data |
1 - 3 of 3
Show
- Genome Browsers
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131341 (1) | 1058 nt | ||
| Genomic | GenBank:JBMGRA010000015 (1) | |||
| Polypeptide | UniProtKB:A0A8M1P7P8 (1) | 194 aa |
- Eghan, K., Lee, S., Yoo, D., Kim, W.K. (2025) 2-Ethylhexanol induces autism-like neurobehavior and neurodevelopmental disorders in zebrafish. Journal of hazardous materials. 488:137469137469
- Li, X., Gao, X., Liu, S., Liu, S., Liu, Y., Gao, L., Xia, L., Liu, K., Jin, M. (2025) 2-Hydroxy-4-n-octyloxybenzophenone induces developmental neurotoxicity and multiple sclerosis-like symptoms through cacna1a regulated Ca2 + inward flow and microglial activation. Ecotoxicology and environmental safety. 295:118154118154
- Palaniselvam, S., Narasimman, V., Vijayashree, R., Ramachandran, S. (2025) Neuroprotective effect of nano-carboxymethyl chitosan from Doryteuthis sibogae against rotenone-induced Parkinson's Disease in the Zebrafish model. Behavioural brain research. :115523115523
- Li, K., Fan, D., Zhou, J., Zhao, Z., Han, A., Song, Z., Tang, X., Hu, B. (2024) Deletion of Slc1a4 Suppresses Single Mauthner Cell Axon Regeneration In Vivo through Growth-Associated Protein 43. International Journal of Molecular Sciences. 25(20):
- Shipman, A., Gao, Y., Liu, D., Sun, S., Zang, J., Sun, P., Syed, Z., Bhagavathi, A., Smith, E., Erickson, T., Hill, M., Neuhauss, S., Sui, S.F., Nicolson, T. (2024) Defects in exosome biogenesis are associated with sensorimotor defects in zebrafish vps4a mutants. The Journal of neuroscience : the official journal of the Society for Neuroscience. 44(50):
- Sugitani, K., Mokuya, T., Homma, S., Maeda, M., Konno, A., Ogai, K. (2023) Specific Activation of Yamanaka Factors via HSF1 Signaling in the Early Stage of Zebrafish Optic Nerve Regeneration. International Journal of Molecular Sciences. 24(4):
- Denans, N., Tran, N.T.T., Swall, M.E., Diaz, D.C., Blanck, J., Piotrowski, T. (2022) An anti-inflammatory activation sequence governs macrophage transcriptional dynamics during tissue injury in zebrafish. Nature communications. 13:5356
- Haraoka, Y., Akieda, Y., Nagai, Y., Mogi, C., Ishitani, T. (2022) Zebrafish imaging reveals TP53 mutation switching oncogene-induced senescence from suppressor to driver in primary tumorigenesis. Nature communications. 13:1417
- Jin, M., Zhang, H., Xu, B., Li, Y., Qin, H., Yu, S., He, J. (2022) Jag2b-Notch3/1b-mediated neuron-to-glia crosstalk controls retinal gliogenesis. EMBO reports. 23(10):e54922
- Takesono, A., Schirrmacher, P., Scott, A., Green, J.M., Lee, O., Winter, M.J., Kudoh, T., Tyler, C.R. (2022) Estrogens regulate early embryonic development of the olfactory sensory system via estrogen-responsive glia. Development (Cambridge, England). 149(1):
1 - 10 of 125
Show