Gene
elavl4
- ID
- ZDB-GENE-990415-246
- Name
- ELAV like neuron-specific RNA binding protein 4
- Symbol
- elavl4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity. Acts upstream of or within axonogenesis. Part of protein-containing complex. Is expressed in heart; nervous system; swim bladder; and trigeminal placode. Orthologous to human ELAVL4 (ELAV like RNA binding protein 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77361 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Hao et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la011022Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| os55 | Allele with one insertion | Exon 3 | Unknown | CRISPR | |
| sa16615 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34358 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45316 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-elavl4 | Hao et al., 2017 | |
| CRISPR2-elavl4 | Hao et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR034918 | HuD, RNA recognition motif 3 |
| Family | IPR002343 | Paraneoplastic encephalomyelitis antigen |
| Family | IPR006548 | Splicing factor ELAV/Hu |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | HuD, RNA recognition motif 3 | Nucleotide-binding alpha-beta plait domain superfamily | Paraneoplastic encephalomyelitis antigen | RNA-binding domain superfamily | RNA recognition motif domain | Splicing factor ELAV/Hu |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QGR7 | InterPro | 403 | ||||||
| UniProtKB:A0A8M6Z808 | InterPro | 369 | ||||||
| UniProtKB:A0A8M9QIF9 | InterPro | 395 | ||||||
| UniProtKB:A0A8M9Q9I0 | InterPro | 398 | ||||||
| UniProtKB:A0A0R4IEW8 | InterPro | 411 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
elavl4-201
(1)
|
Ensembl | 2,109 nt | ||
| mRNA |
elavl4-202
(1)
|
Ensembl | 1,818 nt | ||
| mRNA |
elavl4-203
(1)
|
Ensembl | 797 nt | ||
| mRNA |
elavl4-205
(1)
|
Ensembl | 6,093 nt | ||
| mRNA |
elavl4-206
(1)
|
Ensembl | 5,416 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-elavl | monoclonal | IgG2b | Mouse |
|
Santa Cruz Biotechnology, Inc.
Life Technologies (Invitrogen) Abcam plc MoBiTec Molecular Biotechnology Molecular Probes, Inc. |
506 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(5xUAS:mCherry-elavl4) |
|
| 1 | Hao et al., 2017 | |
| Tg(mnx1-1.5hsp70l:mCherry-elavl4) |
|
| 1 | Hao et al., 2017 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-194K14 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-50D16 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-175G23 | ZFIN Curated Data | |
| Encodes | EST | fc24h01 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:77361 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001244600 (1) | 5416 nt | ||
| Genomic | GenBank:CR931780 (2) | 228591 nt | ||
| Polypeptide | UniProtKB:A0AB32TZW3 (1) | 454 aa |
- Song Rong, S., Larson, A., Wiggs, J.L., NEIGHBORHOOD consortium (2024) ATXN2 loss of function results in glaucoma-related features supporting a role for Ataxin-2 in primary open-angle glaucoma (POAG) pathogenesis. Vision Research. 226:108508108508
- Zhang, S., Yang, J., Xu, J., Li, J., Xu, L., Jin, N., Li, X. (2024) Integrative mRNA and miRNA Expression Profiles from Developing Zebrafish Head Highlight Brain-Preference Genes and Regulatory Networks. Molecular neurobiology. :
- Azbazdar, Y., Poyraz, Y.K., Ozalp, O., Nazli, D., Ipekgil, D., Cucun, G., Ozhan, G. (2023) High-fat diet feeding triggers a regenerative response in the adult zebrafish brain. Molecular neurobiology. 60(5):2486-2506
- Nascimento, L.R.D., Vieira-Silva, G.A., Kitajima, J.P.F.W., Batissoco, A.C., Lezirovitz, K. (2022) New Insights into the Identity of the DFNA58 Gene. Genes. 13(12):
- Soto, X., Burton, J., Manning, C.S., Minchington, T., Lea, R., Lee, J., Kursawe, J., Rattray, M., Papalopulu, N. (2022) Sequential and additive expression of miR-9 precursors control timing of neurogenesis. Development (Cambridge, England). 149(19):
- Kramer, A.C., Gurdziel, K., Thummel, R. (2021) A Comparative Analysis of Gene and Protein Expression Throughout a Full 28-Day Retinal Regeneration Time-Course in Adult Zebrafish. Frontiers in cell and developmental biology. 9:741514
- Picton, L.D., Bertuzzi, M., Pallucchi, I., Fontanel, P., Dahlberg, E., Björnfors, E.R., Iacoviello, F., Shearing, P.R., El Manira, A. (2021) A spinal organ of proprioception for integrated motor action feedback. Neuron. 109(7):1188-1201.e7
- Scott, K., O'Rourke, R., Winkler, C.C., Kearns, C.A., Appel, B. (2021) Temporal single-cell transcriptomes of zebrafish spinal cord pMN progenitors reveal distinct neuronal and glial progenitor populations. Developmental Biology. 479:37-50
- Zimmerman, M.W., Liu, Y., He, S., Durbin, A.D., Abraham, B.J., Easton, J., Shao, Y., Xu, B., Zhu, S., Zhang, X., Li, Z., Weichert-Leahey, N., Young, R.A., Zhang, J., Look, A.T. (2018) MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification. Cancer discovery. 8:320-335
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
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