Gene
vsx1
- ID
- ZDB-GENE-990415-205
- Name
- visual system homeobox 1 homolog, chx10-like
- Symbol
- vsx1 Nomenclature History
- Previous Names
-
- etID309864.17 (1)
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Enables chromatin binding activity and transcription cis-regulatory region binding activity. Involved in regulation of transcription, DNA-templated. Acts upstream of or within several processes, including negative regulation of axial mesodermal cell fate specification; nervous system development; and paraxial mesodermal cell fate specification. Is expressed in blastomere; immature eye; nervous system; and neural tube. Human ortholog(s) of this gene implicated in corneal dystrophy; keratoconus; and posterior polymorphous corneal dystrophy 1. Orthologous to human VSX1 (visual system homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 37 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73233 (8 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
keratoconus | Alliance | Keratoconus 1 | 148300 |
?Craniofacial anomalies and anterior segment dysgenesis syndrome | 614195 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | CVC domain | Homeobox, conserved site | Homeobox domain | Homeobox-like domain superfamily |
---|---|---|---|---|---|
UniProtKB:F1QBH3
|
340 | ||||
UniProtKB:Q6PBV1
|
340 | ||||
UniProtKB:F1QTW3
|
344 | ||||
UniProtKB:O42250
|
344 |
Interactions and Pathways
No data available
Plasmids
No data available