Gene

l1camb

ID
ZDB-GENE-980526-512
Name
L1 cell adhesion molecule, paralog b
Symbol
l1camb Nomenclature History
Previous Names
  • L1.1 (1)
  • nadl1.1 (1)
  • wu:fa30h05
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to enable cell-cell adhesion mediator activity. Involved in cartilage morphogenesis and positive regulation of gene expression. Acts upstream of or within axon regeneration. Predicted to be located in axonal growth cone. Predicted to be active in axon and plasma membrane. Is expressed in nervous system; pectoral fin; and pharyngeal arch. Human ortholog(s) of this gene implicated in MASA syndrome; hydrocephalus; ovarian carcinoma; pancreatic cancer; and schizophrenia. Orthologous to human L1CAM (L1 cell adhesion molecule).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
21 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With l1camb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hydrocephalus Alliance Hydrocephalus due to aqueductal stenosis 307000
hydrocephalus Alliance Hydrocephalus with congenital idiopathic intestinal pseudoobstruction 307000
hydrocephalus Alliance Hydrocephalus with Hirschsprung disease 307000
MASA syndrome Alliance CRASH syndrome 303350
MASA syndrome Alliance MASA syndrome 303350
Corpus callosum, partial agenesis of 304100
Associated With l1camb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR003961 Fibronectin type III
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Domain IPR013151 Immunoglobulin
Domain IPR026966 Neurofascin/L1/NrCAM, C-terminal domain
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Immunoglobulin Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Neurofascin/L1/NrCAM, C-terminal domain
UniProtKB:Q6U7I5 1269
UniProtKB:Q90478 1197
UniProtKB:F1R5A9 1332
UniProtKB:A4JYG6 1125
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations