ZFIN is now using GRCz12tu for Genomic Data
Gene
cbfb
- ID
- ZDB-GENE-980526-440
- Name
- core-binding factor subunit beta
- Symbol
- cbfb Nomenclature History
- Previous Names
-
- unp1266
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables protein heterodimerization activity. Contributes to DNA binding activity and transcription coregulator activity. Acts upstream of or within several processes, including heart contraction; lymphoid lineage cell migration into thymus; and myofibril assembly. Located in Z disc and nucleus. Part of core-binding activity factor complex. Is expressed in several structures, including digestive system; hematopoietic system; immune system; nervous system; and pericardial region. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia. Orthologous to human CBFB (core-binding factor subunit beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Cleidocranial dysplasia 2 | 620099 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Core-binding factor, beta subunit | Core-binding factor, beta subunit superfamily |
|---|---|---|---|---|
| UniProtKB:A0A140LGT1 | InterPro | 201 | ||
| UniProtKB:A0A0B4P506 | InterPro | 174 | ||
| UniProtKB:Q98U16 | InterPro | 187 | ||
| UniProtKB:A0A0B4P4A4 | InterPro | 188 | ||
| UniProtKB:A0A8M9PQ04 | InterPro | 180 | ||
| UniProtKB:A0A0B4PIS7 | InterPro | 187 | ||
| UniProtKB:A0A8M2B5H7 | InterPro | 200 | ||
| UniProtKB:A0AB32T7B2 | InterPro | 179 |
Interactions and Pathways
No data available
Plasmids
No data available