Gene
tncb
- ID
- ZDB-GENE-980526-104
- Name
- tenascin Cb
- Symbol
- tncb Nomenclature History
- Previous Names
-
- tenc
- tnc
- etID309720.5 (1)
- wu:fk04d02
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including axon development; positive regulation of synaptic assembly at neuromuscular junction; and regulation of neuron projection development. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including adaxial cell; central nervous system; hypochord; myoseptum; and neural crest cell. Human ortholog(s) of this gene implicated in allergic conjunctivitis; asthma; autosomal dominant nonsyndromic deafness 56; and pulmonary hypertension. Orthologous to human TNC (tenascin C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Schweitzer et al., 2005
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 56 | Alliance | Deafness, autosomal dominant 56 | 615629 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR002181 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR041161 | Tenascin, EGF-like domain |
| Family | IPR050991 | Extracellular Matrix Regulatory Proteins |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR014716 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 |
| Homologous_superfamily | IPR036056 | Fibrinogen-like, C-terminal |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like domain | Extracellular Matrix Regulatory Proteins | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 | Fibrinogen-like, C-terminal | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | Tenascin, EGF-like domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E9QHI1 | InterPro | 1720 | |||||||||
| UniProtKB:A0A8M6YY54 | InterPro | 1628 | |||||||||
| UniProtKB:F1QYE2 | InterPro | 1811 | |||||||||
| UniProtKB:A0AB32TMU2 | InterPro | 1628 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnc-201
(1)
|
Ensembl | 6,229 nt | ||
| mRNA |
tnc-202
(1)
|
Ensembl | 6,899 nt | ||
| mRNA |
tnc-205
(1)
|
Ensembl | 5,384 nt | ||
| mRNA |
tnc-207
(1)
|
Ensembl | 6,783 nt | ||
| mRNA |
tnc-208
(1)
|
Ensembl | 6,780 nt | ||
| mRNA |
tnc-209
(1)
|
Ensembl | 6,347 nt | ||
| ncRNA |
tnc-003
(1)
|
Ensembl | 524 nt | ||
| ncRNA |
tnc-004
(1)
|
Ensembl | 763 nt | ||
| ncRNA |
tnc-005
(1)
|
Ensembl | 749 nt |
Interactions and Pathways
No data available
Plasmids
No data available