Gene
nlrp3l.1
- ID
- ZDB-GENE-180104-12
- Name
- NACHT, LRR and PYD domains-containing protein 3-like, tandem duplicate 1
- Symbol
- nlrp3l.1 Nomenclature History
- Previous Names
-
- nlrp3l
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to act upstream of or within inflammatory response; innate immune response; and regulation of apoptotic process. Predicted to be located in membrane. Predicted to be part of canonical inflammasome complex. Predicted to be active in cytoplasm. Orthologous to several human genes including NLRP10 (NLR family pyrin domain containing 10).
- Genome Resources
-
- Alliance (1)
- Gene:103910107 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Frame et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Frame et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-nlrp3l.1 | N/A | Frame et al., 2020 |
MO2-nlrp3l.1 | N/A | Frame et al., 2020 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | CARD8/ASC/NALP1, CARD domain | CARD domain | Death-like domain superfamily | Leucine-rich repeat domain superfamily | NACHT-associated domain | NACHT, LRR and PYD domains-containing protein, helical domain HD2 | NACHT nucleoside triphosphatase | NLRP family, innate immunity and inflammation regulators | P-loop containing nucleoside triphosphate hydrolase |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M2BIU4 | InterPro | 836 | |||||||||
UniProtKB:A0A8M3B7W6 | InterPro | 977 | |||||||||
UniProtKB:A0AB32T452 | InterPro | 954 | |||||||||
UniProtKB:A0AB32T6I5 | InterPro | 993 | |||||||||
UniProtKB:A0AB32T7T1 | InterPro | 1021 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
No data available
- Comparative Orthology
- Alliance
- Frame, J.M., Kubaczka, C., Long, T.L., Esain, V., Soto, R.A., Hachimi, M., Jing, R., Shwartz, A., Goessling, W., Daley, G.Q., North, T.E. (2020) Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production. Developmental Cell. 55(2):133-149.e6
- Hu, Y.W., Yu, Z.L., Xue, N.N., Nie, P., Chang, M.X. (2014) Expression and protective role of two novel NACHT-containing proteins in pathogen infection. Developmental and comparative immunology. 46(2):323-32
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