ZFIN is now using GRCz12tu for Genomic Data
Gene
cd80/86
- ID
- ZDB-GENE-150414-1
- Name
- cluster of Differentiation 80/86
- Symbol
- cd80/86 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Acts upstream of or within T cell activation involved in immune response and dendritic cell antigen processing and presentation. Located in cell surface. Part of IgM immunoglobulin complex. Is expressed in several structures, including digestive system; gill; heart; immune system; and integument. Human ortholog(s) of this gene implicated in several diseases, including IgA vasculitis; autoimmune disease (multiple); chronic lymphocytic leukemia; chronic obstructive pulmonary disease; and systemic scleroderma. Orthologous to human CD86 (CD86 molecule).
- Genome Resources
-
- Alliance (1)
- Gene:105667211 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb455 | Allele with one delins | Exon 2 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cd80/86 | Zebrafish Nomenclature Committee |
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Human Disease
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
- Genome Browsers
- No data available
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-cd80/86 | polyclonal | IgG | Rabbit |
|
4 |
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Plasmids
No data available
No data available
No data available
- Genome Browsers
- No data available
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001308063 (1) | 1253 nt | ||
| Genomic | GenBank:CABZ01057088 (1) | |||
| Polypeptide | RefSeq:NP_001294992 (1) | GRCz12tu | 279 aa |
- Comparative Orthology
- Alliance
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | CD86 | 3 | Amino acid sequence comparison (1) |
- Hong, Y., Hu, C.B., Bai, J., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2023) Essential role of an ERV-derived Env38 protein in adaptive humoral immunity against an exogenous SVCV infection in a zebrafish model. PLoS pathogens. 19:e1011222e1011222
- Shao, T., Ji, J.F., Zheng, J.Y., Li, C., Zhu, L.Y., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2022) Zbtb46 Controls Dendritic Cell Activation by Reprogramming Epigenetic Regulation of cd80/86 and cd40 Costimulatory Signals in a Zebrafish Model. Journal of immunology (Baltimore, Md. : 1950). 208(12):2686-2701
- Limonta, G., Mancia, A., Abelli, L., Fossi, M.C., Caliani, I., Panti, C. (2021) Effects of microplastics on head kidney gene expression and enzymatic biomarkers in adult zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 245:109037
- Xie, L., Tao, Y., Wu, R., Ye, Q., Xu, H., Li, Y. (2019) Congenital asplenia due to a tlx1 mutation reduces resistance to Aeromonas hydrophila infection in zebrafish. Fish & shellfish immunology. 95:538-545
- Liu, G.P., Xiang, L.X., Shao, T., Lin, A.F., Shao, J.Z. (2018) Stimulatory function of peroxiredoxin 1 in activating adaptive humoral immunity in a zebrafish model. Developmental and comparative immunology. 84:353-360
- Shao, T., Zhu, L.Y., Nie, L., Shi, W., Dong, W.R., Xiang, L.X., Shao, J.Z. (2015) Characterization of surface phenotypic molecules of teleost dendritic cells. Developmental and comparative immunology. 49:38-43
- Zhu, L.Y., Lin, A.F., Shao, T., Nie, L., Dong, W.R., Xiang, L.X., and Shao, J.Z. (2014) B cells in teleost fish act as pivotal initiating APCs in priming adaptive immunity: an evolutionary perspective on the origin of the B-1 cell subset and B7 molecules. Journal of immunology (Baltimore, Md. : 1950). 192(6):2699-2714
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