ZFIN is now using GRCz12tu for Genomic Data
Gene
inf2
- ID
- ZDB-GENE-140711-5
- Name
- inverted formin 2
- Symbol
- inf2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Acts upstream of or within several processes, including glomerular filtration; podocyte development; and slit diaphragm assembly. Is expressed in several structures, including blood vessel; digestive system; eye; pronephros; and somite. Used to study glomerulosclerosis. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate E and focal segmental glomerulosclerosis 5. Orthologous to human INF2 (inverted formin 2).
- Genome Resources
-
- Alliance (1)
- Gene:792715 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Sun et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Charcot-Marie-Tooth disease dominant intermediate E | Alliance | Charcot-Marie-Tooth disease, dominant intermediate E | 614455 |
| focal segmental glomerulosclerosis 5 | Alliance | Glomerulosclerosis, focal segmental, 5 | 613237 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| glomerulosclerosis | WT + MO1-inf2 | standard conditions | Sun et al., 2014 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-like helical | Armadillo-type fold | Formin, FH3 domain | Formin, GTPase-binding domain | Rho GTPase-binding/formin homology 3 (GBD/FH3) domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9P0A2 | InterPro | 238 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-inf2 | polyclonal | Rabbit |
|
Sigma-Aldrich
|
2 |
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance