Gene
fat1b
- ID
- ZDB-GENE-130530-563
- Name
- FAT atypical cadherin 1b
- Symbol
- fat1b Nomenclature History
- Previous Names
-
- zmp:0000000560 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Acts upstream of or within glial cell development and retina development in camera-type eye. Predicted to be located in membrane. Predicted to be active in adherens junction and plasma membrane. Is expressed in posterior lateral line neuromast. Human ortholog(s) of this gene implicated in colorectal cancer; esophagus squamous cell carcinoma; lung non-small cell carcinoma; lung small cell carcinoma; and oral squamous cell carcinoma. Orthologous to human FAT1 (FAT atypical cadherin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Charlton-Perkins et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Conserved_site | IPR020894 | Cadherin conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001791 | Laminin G domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR002126 | Cadherin-like |
| Domain | IPR049883 | NOTCH1 EGF-like calcium-binding domain |
| Family | IPR039808 | Cadherin |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR015919 | Cadherin-like superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cadherin | Cadherin conserved site | Cadherin-like | Cadherin-like superfamily | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Laminin G domain | NOTCH1 EGF-like calcium-binding domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PBP8 | InterPro | 4503 | |||||||||||
| UniProtKB:A0A140LGD3 | InterPro | 4481 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance