Gene
cep152
- ID
- ZDB-GENE-111005-1
- Name
- centrosomal protein 152
- Symbol
- cep152 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to be involved in centriole replication. Predicted to be active in centrosome. Human ortholog(s) of this gene implicated in Seckel syndrome 5 and primary autosomal recessive microcephaly 9. Orthologous to human CEP152 (centrosomal protein 152).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Sepulveda et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary autosomal recessive microcephaly 9 | Alliance | Microcephaly 9, primary, autosomal recessive | 614852 |
| Seckel syndrome 5 | Alliance | Seckel syndrome 5 | 613823 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR051235 | Centrosomal Protein 152/SHC-Transforming Protein |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Centrosomal Protein 152/SHC-Transforming Protein |
|---|---|---|---|
| UniProtKB:A0A8M3AZU2 | InterPro | 1559 | |
| UniProtKB:X1WBK2 | InterPro | 1560 | |
| UniProtKB:A0A8M3AWQ9 | InterPro | 1550 | |
| UniProtKB:A0AB32TLB2 | InterPro | 1557 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cep152-201
(1)
|
Ensembl | 3,730 nt | ||
| mRNA |
cep152-202
(1)
|
Ensembl | 5,185 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-147F23 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009298144 (1) | 5071 nt | ||
| Genomic | GenBank:CU372926 (2) | 91752 nt | ||
| Polypeptide | UniProtKB:X1WBK2 (1) | 1560 aa |
- Comparative Orthology
- Alliance
- Sepulveda, G., Antkowiak, M., Brust-Mascher, I., Mahe, K., Ou, T., Castro, N.M., Christensen, L.N., Cheung, L., Jiang, X., Yoon, D., Huang, B., Jao, L.E. (2018) Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates. eLIFE. 7
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Zhou, F., Narasimhan, V., Shboul, M., Chong, Y.L., Reversade, B., Roy, S. (2015) Gmnc Is a Master Regulator of the Multiciliated Cell Differentiation Program. Current biology : CB. 25(24):3267-73
- Gómez-Requeni, P., Conceição, L.E., Olderbakk Jordal, A.E., and Rønnestad, I. (2010) A reference growth curve for nutritional experiments in zebrafish (Danio rerio) and changes in whole body proteome during development. Fish physiology and biochemistry. 36(4):1199-1215
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